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I can highlight a subject that i need to remove but nothing happens
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Try to reset the preferences of Photoshop using the steps described here:
https://helpx.adobe.com/photoshop/using/preferences.html#reset-preferences
It's recommended to backup your settings before resetting the preferences.
See here: https://helpx.adobe.com/photoshop/using/preferences.html#backup-photoshop-preferences
If this doesn't help we need more informations.
Which tool or function do you try to use for removing?
Is the appropriate layer is active?
Please provide also a copy of your 'System Info'. This can be get from the Photoshop menu item Help > System Info. There's a copy button in the System Info dialog. Press this button and paste the info into your next forum post.