Help! How to save a PNG and retain all blend modes for every layer

Blending modes are applied by whatever software is doing the compositing. As long as the images are layers in one Photoshop document, the Photoshop compositing engine can apply the layer blending modes as it renders the document preview.

But if it isn’t acceptable to merge the layers into a single PNG file with overall transparency, because for some reason you need to export each layer as a separate file (in any format that supports transparency, not just PNG), when you bring those PNG files into another application to be re-combined they will no longer be composited by Photoshop and can no longer use Photoshop blending modes. They are now being composited by whatever software you brought them into.

For email marketing, you must already have an idea of which web and standalone email clients you are targeting. Because email marketing formatted to modern standards should support CSS, one potential solution is to apply blending modes to those PNG layers within the email itself, in the CSS code for that email. In that way, you let the email client app or web browser webmail client do the compositing using its CSS blending mode support.

Just be aware that some of your targeted email clients and web browsers may not support as many CSS blending modes as are available in Photoshop. If that happens, you must design using the blending modes that you can count on to be available in your targeted email clients and web browsers.

I would try selecting all layers, but with background turned off, and making a Smart Object.  This should retain the look of the combined document, so will save out to PNG with transparent background just like you created it.

PNG doesn't have layers, so there would be no blend modes. When you export a PNG, you can specify transparency. Have you tried using Save for Web?