How can i remove small pixels in photoshop?

[Gökhan305670307wv8]

I need to print my images but pixels smaller than 20 at 600dpi causing me problems. I do have tons of them so manual is not worthy. I already tried Dust & Scratches but it distorts my images and creates another small pixels-islands. Does anyone have any idea?

[Semaphoric]

I would try the Maximum or Minimum filters.

[Stephen Marsh]

@Gökhan305670307wv8 – I agree with @Semaphoric dupe the image layer, run the Filter > Other > Minimum at a value such as 12px or whatever is required. This will destroy unwanted and wanted detail. Then add a black layer mask hiding all content. Then with a solid white brush with a hard edge (perhaps a square brush tip), paint over the areas that you wish to remove. The mask will then only show the filtered areas where you have painted.

[Trevor.Dennis]

Another approach would be Topaz Simplify.  I have no idea what it costs now (I have owned mine for 20 years).

[c.pfaffenbichler]

What’s with the colors – are they relevant? 

Can you provide a file?