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The keyboard shortcut for export / save for web is no longer working.
(Command + Option + Shift + S )
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Hi @brendab62532299 works fine on my Mac - go to Edit>Keyboard Shortcuts and make sure you are on the Default set.
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Let's make sure we're in a default state and there are no stale settings somewhere:
Restore your preferences using this manual method:
https://helpx.adobe.com/photoshop/using/preferences.html#Manually 
Does it work correctly?
If that doesn't solve it, you can quit Photoshop and put the Settings folder back.
It may help if we could see your Photoshop System Info. Launch Photoshop, and select Help >System Info...and copy/paste the text in a reply.
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I have the same problem. Doesn't work in Illustrator or Photoshop.
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I had the same problem spring up last week... probably about the time I ran a MacOS update.
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Same here. I checked Keyboard Shortcuts and it's set correctly, but still doesn't work. It simply doesn't do anything. Using Monterey 12.6.6 and Photoshop 24.5.0.
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I have this issue too. Happened for me when I updated to latest Photoshop (24.5.0). I tried editing the keynoard shortcuts and have currently switched to Apple Alt Shift D, which works fine. When you change it to Appe Alt Shift S, though, nothing happens (the edit shortcuts won;t even register the S key), so it's as though the S key is being ignored/overridden. (Could also be Ventura 13.4, as Ventura & Adobe don't seem to terribly happy together…)
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Piling up here. Does not work.
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This happened to me. For me it was the Webex app stealing the keyboard shortcut. Disabled it in Webex and now Cmd-opt-shift-S is working again!
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I noticed the shortcut started working again randomly, but we just got rid of Webex at work so it makes sense! ha.
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That's it!!! It was Webex all along! Good grief. The one place I never thought to look… Problem solved.
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OMG! Thank you for sharing it was Dag Gum WebEx that was over riding the short cut! I never ever would have thought about that! I have been dealing with this for over a year!
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If you are like me = have Webex installed but not sure what shortcut is being disabled or where to look, it is "Switch between floating windows" (for me at least). Located in File > Open keyboard shortcut search.
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That was it!! Thank you!
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it was WebEx for me as well - crazy