Layer alignment

Though Photoshop layers limit is 8,000 layers, you most likely would not like Photoshop performances working on a document withe 8000 layers on a super computer.  You had been given advice start small do not try 300.   Its good advice.  Adobe's Photoshop Script menu File>Scripts>Load File into a stack should be helpful if you camera was on a tripod and most of the scene before the camera remained stationary in the camera's viewfinder.  In its dialog you can create a file list a subset of your 300 files and it will load them into a photoshop document and optionally try to align the images in the stack.  If successful you can make a centered  crop, create a frame animation and render out an MP4 that displays your time lapse.  You want to user MP4 not an Animated Gif.  Mp4 supports color well Gif does not. You can use Photoshop to splice MP4 together.

This is a huge undertaking for layer alignment and we had another post just last week similar to this.

It was taking over 4 hours to complete 270+ layers.

Having your images on your local HD helps speed this up, but also splitting this into 100 layer alignments helps too.

Then flatten and align the three files to finalize.

Not sure exactly why you would need all 300 layers to complete this.

Experiment with just a few layers first before trying with all. I would personally break it down into smaller chunks. Here is some info on stacking images for movement. https://photoshoptrainingchannel.com/remove-tourists-stack-mode/