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So when I use photoshop the mouse will only work if I hover it over the taskbar. If not the mouse after performing a single function no longer works. As if it doesn't even know Photoshop is there. hovering on the taskbar is the only way it resets and "finds" photoshop again.
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What have you done for all-purpose trouble-shooting so far?
Restoring Preferences after making sure all customized presets like Actions, Patterns, Brushes etc. have been saved might be a good starting point:
https://helpx.adobe.com/photoshop/using/preferences.html
https://helpx.adobe.com/photoshop/kb/basic-trouble-shooting-steps.html
https://helpx.adobe.com/photoshop/kb/troubleshoot-gpu-graphics-card.html
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I also have this problem. Doing ANY action with the mouse seems to freeze Photoshop until the mouse moves over the windows taskbar. I have no idea what is causing this unfortunately. I tried resetting everything I could think of to factory defaults (including hardware drivers, etc, etc) and the issue is still present. It basically renders photoshop unusable.
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Update: looks like disabling the option at Preferences > Techno Prevs > Deactivate Native Canvas might be a possible work around.