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And for the 1000ppi,what you mean is that the only downside of working on that resolution is the biggest size of the file on the HD?

Aside from the file-size applying Filters, saving etc. take longer.

But if it’s not a noticeable nuisance you should stick with the higher resolution, in my opinion, for the benefit of having a little buffer for larger outputs.

Yes it's old school ligne claire..I sample handmade watercolor and put them as layer on my black and white drawing in Photoshop.

Is the line drawing pure black (0%C, 0%M, 0%Y, 100%K)?

That can be useful in case the registration is not very exact in printing to avoid color fringes along the lines.

It's working pretty well for me so I'd like to know why is Photoshop not so good for comic creators,i'll do a search:)

Type and graphical elements like lines (both for the speech balloons and the panel frames) would benefit from vector output but Photoshop’s capabilities are somewhat limited in that regard.

And while combining, transforming and re-arranging individual elements and frames can be done lossless-ly with Smart Objects that may not always feel very convenient.

what you mean is that if I work in CMYK I should apply color management?

Always embed the profile when saving CMYK images so that one can later one be sure for which standard print condition they were intended.

Only in very special cases would an unprofled CMYK image make sense in my opinion – for example if the only colors are 100% black and primary or secondary colors like a 0/100/100/0 red.

(Naturally one should also always embed the profile in RGB files, otherwise others with different RGB Working Spaces may see the image displayed and printed very differently.)