Adam, Tried 32bit and 64bit. Disabled all plug in. Cleared both Photoshop and OS font caches. Closed all panels. Still get system freezes. Clearing the font caches helps a little bit. Or rather appears to help, but really doesn't just makes things a tad smoother for a few minutes then it's back. Same holds true with closing all Panels. Appears to help for a few moments, then back to what it was. I also get the blinking panels on the second monitor when I am able to use CS5 for anything (which honestly isn't often). All I need do to see the issue is open and close files with Photoshop 12.0.1. Simple files, like 72ppi flat jpgs. Eventually the entire system will freeze up and sputter. If I can use it, then background it. Trying to bring it forward and open an image later almost always results in a major sputter for 30-45 minutes or more. I did lose a hard drive this week due to unrecoverable sectors. It was my boot drive. So, naturally, I assumed that could have been the problem all along. But yesterday I tried Photoshop CS5 again with a new drive... same issue. I've also gone so far as to wipe a drive in an internal bay and install OS10.6.3 and only the wacom driver and Creative Suite 5 Design Premium. I have the same exact issue on that OS although it seems harder to reproduce, nonetheless it's there. MacPro 1,1 24GB RAM 2 dedicated scratch drives (not partitions) 2 nVidia 8800 GT cards All other software has been running flawlessly on this system. I'm considering a new MacPro. If I do that, I'd be more than happy to loan Adobe this MacPro (with a reciept of course ) which shows the issue, before I sell it. West coast here... southern Oregon. For what it's worth, I've also got CS5 installed on a 2.4Ghz MacBookPro (OS10.6.4) ... it seems to run absolutely fine there. But, admittedly, it's not used that much on the MacBookPro.
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