Reformatting is definitely a nuclear solution. I was having a similar problem, though it had nothing to do with Mighration Assistant. I've been using CS6 without issue for months until today. I would try opening Photoshop CS6 from a shortcut on my dock, (I have a MacBook Pro with Lion), and right after the splash screen, I would get the Beachball of Doom, plus a white rectangle where the "Participate" "Do not Participate" box would normally appear. I verified and repaired my disk using Disk Utility, restarted my machine, but continued to have the same problem. Finally, I decided to try a simple approach, which, in this case, actually worked! Rather than trying to open CS6 from the shortcut on the dock, I decided to open one of my saved .psd files directly. Amazingly enough, the program opened along with the file, and I'm able to use Photoshop again. Still not sure why this was an issue to begin with, and I'd like to figure that out. However, in the meantime, if you're having this problem, too, try opening one of your .psd files, and maybe you'll have some luck.
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