You need to identify the element that is crashing your file. Saving it as an .IDML might fix it, but if not you need to start working out exactly what element is causing the crashes. Start by duplicating the document, so you have a back-up copy. If you know roughly where the crashing page is, try deleting all the pages except for a couple either side of it, so keep perhaps page 50 to 60. See if that document still crashes. If it does then delete half the pages and see if it still crashes. If it does, then the problem page/element is in the other half. So go back and delete the opposite half of pages and so on and so on until you've narrowed down the page or spread that the issue is on. Try updating all the links on the offending page/s first and see if that fixes it (just update them with a generic link). If so then try replacing the links one at a time and you'll find which one is crashing it, and be able to replace it with a resaved version. I have had instances where it was text that was causing the issue too. In that case, once you have established which page is causing the issue, you need to remove just that page/s and insert blank page/s to replace it. Then you can go back to either a PDF to get that text, or you original. Save it as unformatted text (use Text Edit) and then reimport that bit (we suspected in our case that it was something that had come in with an impot form MS Word). You'll obviously need to restyle the text once it is back in your document, but the rest of your document will still be intact. But hopefully just saving as .IDML will sort it out!
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