P: Print Module, Page Set Up Crashes Lightroom Classic V 12.0.1

Sorry my bad. When you wrote you lost your custom print presets, I incorrectly thought you lost your Custom Print settings (Templates) in LR. Your Epson custom print presets are gone. You'll have to recreate them in the Epson print driver. 

I've tried backing up the plist files and such, and some have suggested it is doable. But it has never worked for me. 

I to have Macbook Pro Ventura 13.0.1 and Canon printers.  I reloaded the print drivers with no improvement.  I have had Adobe support take control of my computer three times as they manipulated various settings, all to no avail.   They are supposed to call me again today, but since they have said they would call x 3 and didn't I'm not holding my breath.  Thanks for your input.

I'm sorry @ThE5008682 digitaldog, I'm not quite sure what the steps should be. I opened LR, un-selected the option, closed the window: no prsets. Opened the window and selected the option again: no presets. Unselected the option, shut LR, re-opened it, no presets. Should I restart the computer?
I doubt that this will do the trick, because the settings this option refers to are in images>lightroom>lightroom-settings. I cannot find printer presets in that folder.  The files that have the presets are in the library>preferences folder, and are called (e.g.) com.apple.print.custompresets.forprinter.EPSON_Epson_Stylus_Pro_3880.plist. LR apparently doesn't recognize the file or can't find it, and I don't know how to make it see what is there. Here is an explanation, only this didn't help me, perhaps it has something to do with file formats ??? https://www.dpreview.com/forums/thread/3783069  What I have is an xml-file.

I more or less did what digitaldog suggests, and it worked, but the result was that I lost all my custom print presets.

Check your preferences for “Store presets with Catalog” (toggle on/off): did this reload your presets with one option?

I am running my LrC (v. 12.0.1) on my MacBook Pro 2020 with M1 chip and Ventura (v. 13.0.1). I have no problem in editing my pictures or to use the Print modul exept for when I press the button Utskriftsformat (SV) (probably Print format in english), then the program crashes and closes unexpectingly. This has happend with the last update. I am in the middle of printing a large series and can't change from A4 to A2, due to this. A real nuisance 

So frustrated with Adobe Customer Service.  I have had a total, I believe, of 5 sessions, with Adobe, three in which they assumed control of my computer and unable to stop the crashing.  What is most disppointing is they have promised THREE TIMES to call during a defined window....so I hung around on three separate occassions for two hours each time waiting for a phone call from them AND THEYNEVER EVEN BOTHERED TO CALL AND CANCEL THE APPOINTMENT!  If you schedule an appointment and can't make it, at least Adobe should have the common curtesy to call me and apologize and reschedule.

By @JSAbrahamson

This is a user-to-user support forum; we can attempt to help you with your issue we can't nor will we help you with Adobe phone support because that isn't the aim of this user-to-user support. 

Moving on: 

Try logging into another account (you may need to make one), still crashing? 
Try starting up in Safe mode (hold down Shift Key when booting), still crashing? 
You might want to try running a free utility like Onyx: still crashing? 
https://www.titanium-software.fr/en/onyx.html
Also view:
https://www.macworld.com/article/352902/onyx-review-macos.html
https://www.macworld.com/article/224955/how-to-reset-a-macs-nvram-pram-and-smc.html
From Adobe:
https://helpx.adobe.com/photoshop/kb/basic-troubleshooting.html

Deleted all Epson printers, same issue with the Brother Printer......

By @JSAbrahamson

Sure, that's a fix for Epson printers.

You can try a similar approach for Brother printers, but I have no idea if that would work. 

So frustrated with Adobe Customer Service.  I have had a total, I believe, of 5 sessions, with Adobe, three in which they assumed control of my computer and unable to stop the crashing.  What is most disppointing is they have promised THREE TIMES to call during a defined window....so I hung around on three separate occassions for two hours each time waiting for a phone call from them AND THEYNEVER EVEN BOTHERED TO CALL AND CANCEL THE APPOINTMENT!  If you schedule an appointment and can't make it, at least Adobe should have the common curtesy to call me and apologize and reschedule.

Deleted all Epson printers, same issue with the Brother Printer......