P: Shortcuts using Alt key aren't working correctly (e.g. Alt-Backspace)

I already posted on the main Adobe forums, but I wanted to come here and do my part to escalate the seriousness of this issue.  I have been using Photoshop for 19 years and I work as a professional designer.  I taught Photoshop classes for 8 years and literally the first thing I did after having the students make a new document was press Alt-Backspace and Ctrl-Backspace about 20 times to get a feel for the proper way to fill something. 

I consider this to be THE most basic function in Photoshop and for it to become broken by a CC update is... disturbing, to say the least.  Please stay focused on keeping the important, basic features of the program working properly instead of adding more bloat and pointless bells and whistles.

Same problem here (Win 10) even the psassistant doesn't help
It's a huge trouble! Ctrl + Alt + Z is like daily water!
Also Alt + Backspace is highly used in my case and needs to hit the keys two or three times.

same problem here, but also things like CTRL+Z (undo) or CTRL+ALT+0 or CTRL+ALT+I or CTRL+ALT+C etc... so many keyboard shortcuts either not working at all, or working very randomly.

Also works partially for me: alt+backspace works from the first hit but things like changing blending modes still don't :(. Thanks though

I have the same issue with all alt-hotkeys, like alt+shift+letter hotkeys for changing blend modes: they BEEP first and work on the second hit

This partially works for me; the shortcut on the keyboard works perfectly now. However, it still doesn't work on the remote button I have set to the same shortcut. At least it doesn't make the error noise anymore, though.

Just uninstall it and install previous version via Creative Cloud . It's so easy and you can continue earning money.

We found a temporary solution at work that gets rid of this annoying issue. 

Go here: https://code.google.com/archive/p/apssistant/downloads
And download the latest version: APssistant 0.8.0.0.7z

Unpack the zip file -> run config -> disable the things in the hotkey tab (I don't know what they do) -> make sure "disable alt menu" is checked in the "anti-disturb" tab -> In the general tab, press "browse" and find photoshop 2018 (program files -> adobe -> photoshop cc 2018 -> photoshop) and select it. 

And there you go, it works as normal again. At least I haven't run into any issues yet. 

This is intensely annoying. Please tell us that we don't have to wait till the next full release to get this bug fixed.  CC2018 Windows 10

Here too @ save for web. Shortcut works only every third or fourth time. Even not possible to type in number at font line-height. outputs a random number.

uninstalled it and installed 17