Does it matter if our assets are disapproved in large numbers?

As @daniellei4510 said, there is no clear cutoff for knowing how many rejections are too many. However, if you are continuing to earn a high rejection rate, that means that you aren't learning from your rejections. You you should study each one carefully to understand what errors are leading to rejection. If you can't edit out those errors, don't submit them.

In theory, yes...it can lead to a suspension. We don't know the exact cut-off point, but we generally recommend a minimum of a 50% refusal rate. If you've had numerous refusals, you can always point one or two assets here and we can make suggestions for improvement.