Blue distorted random frames when previewing or rendering

I'm almost positive that your footage is an MP4. Sometimes it's GPU drivers, other times the only solution is to drop the original footage in the Adobe Media Encoder and render it to a Production format like ProRez.

The standard procedures apply: Check your hardware acceleration settings, update your system's graphics driver, turn off GPU usage to test an/or if nothing else works. That goes both for AE and AME.

Mylenium