Cant save preset

Try changing the permissions as suggested in the following article: https://helpx.adobe.com/in/x-productkb/multi/preferences-folder-read-only-error.html

Let us know how it goes.

Thanks,

Nishu

Could there be a permissions issue preventing this from happening?

If you can find the same file in C: drive, you just copy it into E: drive. If not, you create a fake file with the same file name.