Extremely slow render with multiple adjustment layers

It is impossible to say what is causing the slowdown without seeing the layers and their modified properties. It make take several screenshots. Multiple Adjustment layers is a bit of a red flag. Most of the time it is more efficient to just put an effect like Lumetri in one layer and if you only want the effect to affect a part of a layer, you can use a mask and enable compositing options. 

Fifty applications of Lumetri in a single comp is going to slow things way down no matter what you try to do. If you need different colors for lights you might consider a shape layer with multiple different sized filled shapes that are different colors, maybe some blur, and then blend modes. That would render much faster than fifty masked adjustment layers with one or more color correction effect applied. 

If you can't find a more efficient workflow you may just be stuck with the render time. I suggest you break your comp up into several shorter comps, each 30 seconds or less, then, after all the pieces are rendered, drop them into Premiere Pro and render your final video there. Asking After Effects to spend 3 days on a render intensive project without running out of memory or hanging up is a lot like handing a loaded gun to a three year old. Something bad is bound to happen. Mose of my comps are single shots and most shots in my movies are less than 7-seconds long. I render almost all comps, and any project that takes more than a couple of seconds a frame to render are always rendered as Image Sequences so that I can pick up where the render fails or just fix 10 frames that the client doesn't like instead of re-rendering 200 of them.

I don't know if I helped you at all, but if you only follow the advice of rendering a few seconds at a time, you will have a lot higher chance of completing the project.