Would emptying Disk cache while exporting with Media encoder speed process?

Sorry man but you're wrong lol I actually have the same exact problem as well. The only way I can get a project out completely is piecing it in Premiere Pro. I get what you're trying to say but no. 

You are dancing around the issue. You have written lengthy posts, but not given any solid technical info about your computer, the project contents, render settings and for that matter what exact warnings you get at which point. Floating wrong assumptions about flushing disk caches, which as @P.M.B said already has nothing to do with final rendering is not in any way useful. And on a more generic level the old rule applies: Out of memory errors rarely have anything to do with actually running out of memory. They are typically just leaks in drivers, CoDecs and DLLs, which translates to that you may need to do a littlke system maintenance rather than trying to lokk for a solution from within the Adobe apps. Begin by updating your graphics driver and checking hardware acceleration options in AE and AME...

Mylenium

If I am going to use the Adobe Media Encoder I always open it before I am finished with the comp. This saves a lot of time. When it is just sitting open in the background your system resources are not taxed enough to make any difference at all in your workflow. 

I only use the AME for comps that render fairly quickly. If render times are expected to go over a few seconds a frame I always use a background rendering tool. My Favorite is RenderGarden. I have 5 and RG is the most efficient. I can render a production master and an MP4 for the client and keep working in AE with no significant performance hit, and my render times are cut by more than 50% on my MacBook Pro and about 80% on my iMac Pro. You also retain full GPU rendering support with RG.

ram has nothing to do with rendering.  And what good is peicing it together in premier?  You still have to get it out of Premier by rendering.  Also putting into premier does not require rendering it in pieces first so I can't understand why you

would be doing that or how it solves your problem.   All in all it's difficult to make sense of your post. 

Most people have no problem which means your issue is likely related to your hardware or workflow and you've offered no information about the specifics of your projects contents, render settings, etc.   And you've offered no information about your hardware other than you having 25 gigs of ram (which is irrelevent) and that you have no external hard drive.  If you want suggestions you have privide relevent details.

https://community.adobe.com/t5/after-effects/faq-what-information-should-i-provide-when-asking-a-question-on-this-forum/td-p/3928960