Adobe digital editions version 4.5 and 3.0 no longer working with Window 10

I've used adobe digital editions 4.5 for about 1-2 months before it crashed following the downloading of an ebook through a trusted source. Since then, I removed the program multiple times, reinstalled it, in vain. I've cleaned my computer, checked for virus, but found absolutely nothing. I am no longer able to use the program to read ebook. I do not know what to do next. I even created a new user profile on my computer and it worked but only for 1 hour before it crashed again. I've tried this about 4 times, and got the same result every time. I now have no mean to read ebook, which is very unfortunate as it was a wonderful program. When I run a troubleshooting program on it, it says that ADE is incompatible with my computer...it wasn't before though, 1-2 months ago. Do you have any idea of what the problem may be? Thank you!