Adobe no longer supports that very old version (CS6 is newer, and is also not supported)
CS3 and Acrobat 8 activation server is retired see reply #1 https://forums.adobe.com/thread/2372929
-you MUST use the special serial number AND the special installer you download, not your originals
-above includes a link to get the special version AND links to help with activation problems
-more information on activation problems with the new version https://forums.adobe.com/thread/2385900
Even with the above information, CS3 is so old that it may not work on Win10
Two ideas that MAY work to install and/or run old programs in Windows 10
-RIGHT click the program icon or EXE and select a compatibility mode in the pop up option window
-or Run as Administrator http://forums.adobe.com/thread/969395 to assign FULL Windows permissions may help... says Encore, but sometimes required for ALL Adobe programs (this is NOT the same as using an Administrator account)