Creative Cloud / Office 365 conflict

We're an agency that uses the Adobe Creative Cloud 2017 versions on Macs using OS Sierra V10.12.1. We have recently installed the Microsoft Office software but are having issues that at frequent points, when we go to launch a Word/Excel/PPT file while an Adobe file is open, it locks up the machine and requires a restart. We have tried reinstalling the Office software but are still having the same issue. Are there conflict issues between Adobe and Office when using simultaneously that can be rectified?