Does Design Premium CS4 software work with Windows 10

Two ideas that MAY work to install and/or run old programs in Windows 10
-RIGHT click the program icon or EXE and select a compatibility mode in the pop up option window
-and/or select Run as Administrator to assign FULL Windows permissions
-also https://helpx.adobe.com/x-productkb/global/create-local-administrator-account-windows.html

Also, while not CS4, I have Acrobat Pro from CS5 that I installed on an earlier Windows... when I used the free upgrade from Microsoft I did not de-activate and reinstall, I simply let Win10 take care of the upgrade... and Acrobat still works

Before you upgrade to Win10,

1. De-activate CS4 on Win7. 

2. Uninstall CS4 and use the Adobe Cleaner Tool to remove old system files.

https://helpx.adobe.com/creative-cloud/kb/cc-cleaner-tool-installation-problems.html

3. Have your CS4 serial number and installation disks ready to re-install on top of Win10.

Hi

You can take a look at this thread, people have it working on Windows 10 but that's not to say that you won't run into issues

https://community.adobe.com/t5/get-started/is-cs4-compatible-with-windows-10/td-p/7382847