Maybe, but it's no guarantee. You need to check your system against the requirements for each program you wish to run - https://helpx.adobe.com/creative-cloud/system-requirements.html . Most modern Macbook's can run most of Adobe's software, but if you are into heavy video production, you may need more than what an entry level Macbook provides. However if you get a used Macbook, there is a possibility that you cannot run any of the programs if it is too out of date.