Acrobat failed to load its core dll - Windows 2 Go Stick

Hello everybody,

we're using Adobe Acrobat DC Standard Version 2015.006.30279 on Windows 2 Go Sticks in a business environment and do receive the following error message "Acrobat failed to load it's core dll" at startup of Acrobat.

This error does only occur on our Windows 2 Go Sticks with Windows 8.1 64Bit installed and we have found out, that it's a reproduceable issue. The problem does not occur on our Workstations and Notebooks.

We found out, that the root cause of this problem is Windows patch/update KB4012216 March 2017 Security Monthly Quality Rollup for Windows 8.1.

After installing this patch, Acrobat isn't working anymore ("Acrobat failed to load it's core dll" message appeared). When I manually uninstall/rollback this patch -> Acrobat is working again.

It would be great if you have any suggestions, workarounds or even a solution for this issue.

Thank you very much