Configuration Error. Please uninstall and reinstall the product. Error: 1

This error box is now coming up on more and more machines in our organisation. Although I have seen various forum posts for Errors 15 and 16, I have seen none for 1. Even Adobe's own support site only mentions 15 and 16, and the fix for this is to correct the permissions on certain folders. These folder permissions are correct on our installations.
We are running Creative Cloud 2018, and this occurs on all applications
Previously we fixed this by uninstalling and reinstalling on a few individual machines, but now the problem is becoming widespread. Ideally we would like to understand the cause of this and prevent it, because remediating it after it has occurred is not a practical option, as we are a University with over 5,000 installations used by multiple students.
Any help would be appreciated.
DaveB