Create gaps for rectangle frames

here is what I do:

• while drawing a frame
• keep mouse button pressed
• press arrow up/down to create more or less rows of frames
• press arrow left/right to create more/less columns of frames
• press Ctrl+Arrow up/down to increase/decrease the heigth of the horizontal gap between frames
• press Ctrl+arrow left/right to increase/decrease the width of the vertical gap between frames
• then let the mouse buttin go

or

• Create the first frame (keep it selected) and Edit>Step and Repeat

If they are already created, teh advanced options in the Align panel allow you to set a measurement of the gap between the shapes 

Despite Willi's answer, I am completely unclear on what you mean and what you're trying to achieve. Could you explain in a little more detail?

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