eyedropper not working Mac

One non-permission gotcha to rule out

If the Eyedropper icon is greyed out or unclickable:

Make sure you’re not in a modal tool (text editing, transform mode, etc.)

Try pressing I on the keyboard to force-select it

Check you don’t have a locked layer / object selected 

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Try resetting your preferences:
InDesign 19.3 and newer go to Preferences > General > and click on "Reset Preferences on Quit" and then quit and restart.

Or
Windows: Start InDesign, and then press Shift+Ctrl+Alt. Click Yes when asked if you want to delete preference files.
macOS: While pressing Shift+Option+Command+Control, start InDesign. Click Yes when asked if you want to delete preference files.
A dialog will appear asking to delete the InDesign Preferences, select 'Yes' on this dialog.

More in-depth cleanse of preferences
https://helpx.adobe.com/in/indesign/kb/indesign-preferences-support-file-locations.html

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Sounds like a macOS privacy permissions glitch, not you doing anything wrong I’ve seen this a few times on new Macs.

A few things to check (in roughly the order that usually fixes it):

Re-check Privacy & Security permissions (don’t just assume they stuck)

Go to
System Settings > Privacy & Security

Then check all of these for the affected app (Illustrator / InDesign / Photoshop - whichever you’re using):

• Screen Recording 
• Accessibility 
• Input Monitoring 
• Full Disk Access (not always required, but worth enabling)
  >If the app is listed but unchecked, check it.
  >If it’s checked already  toggle it OFF, then ON again.

Quit the app completely (not just close the window)

After changing permissions:

• Quit the app
• Make sure it’s not running in the background
• Relaunch it
• macOS does not re-grant permissions until a full relaunch.

Restart your Mac 

If it still won’t click: reset macOS permissions for the app

This clears any corrupted permission state.

Open Terminal and run (replace with the correct app):

tccutil reset ScreenCapture com.adobe.InDesign

Then:

Relaunch the app

macOS should ask for permission again