InDesign Crashes on Launch with “A Serious Error Was Detected” Even After Reinstalling

Hi ​@yan_0624,

I hope the suggestions shared by the experts helped resolve the issue. Could you please let us know if InDesign is now launching properly or if you are still facing the same crash message?

If the issue continues, kindly share your macOS version and confirm whether the crash happens immediately on launch or after opening a specific file, so I can check this further.

Looking forward to your update.
Abhishek

Are you using any third-party plug-ins with your InDesign? If so try disabling them and see if the problem persists. If third-party plug-ins are the source of the problem then go to their website and make sure that they are up to date and designed to be compatible with your version of InDesign.

https://helpx.adobe.com/ie/creative-cloud/apps/troubleshoot/diagnostics-repair-tools/run-creative-cloud-cleaner-tool.html

Try these general troubleshooting steps first:

https://www.rockymountaintraining.com/adobe-indesign-rebuilding-preferences-cache/