Intermittent issues with permissions (saving files) with Indesign and Windows Server 2012 R2

We have a team of about 35 graphic designers on Macs that uses a Windows server 2012 R2 file server as their main work area. All machines are bound to Active Directory.

For years now we have had intermittent issues with permissions - folders or files locking out, sometimes in the middle of work, not letting the user save the file, other times it saves, but when you come back the file can't be saved or deleted and sometimes the problem happesn on the whole folder containing the file.

The way to fix it as an administrator is to go to the windows server, take ownership of the folder and propagate permissions - if we don't take ownership, the permissions reset fails.

We have tried using SMB connections and AFP connections (using Acronis Files Connect). The issues happen with both connections.

Has anyone has had a similar issue and can shed some light on the problem?

Thanks!