JPEG with hyperlinks?

The best way I have found would not be with Adobe InDesign, but with Microsoft Word and Photoshop.

Slice up your image as Steve suggested... slice for the main portion of your image and then an additional slice for each region you need to add a hyperlink to.

Make your slices all the way across your image from left to right from top to bottom to keep the regions for hyperlinks simple... preferably slice the areas of the image that contain the type for the email address, web address, any other type you want to associate with a hyperlink.

In Word, create a table with the same amount of slices... 1 column and X amount of rows for each of your slices... remove the line for stroke color and width of the table strokes to None... 0 cell padding.

Insert each slice into each of the table rows... Word is pretty good at inserting your images at the absolute size to fit automatically, and each image should come together to make your whole original image.

Then select each table region needed for the hyperlink and ad the hyperlink in Word. Save your Word document.

Then, select the whole table and past it into your email text area.

With luck your hyperlinks will also paste into the email. At minimum, the table with images should paste in and look like one whole image. If for some reason the hyperlinks do not also paste into your email,  you can respecify each region for the hyperlinks as you did in Word, but using the email program.

Hope this helps.

Unfortunately, that is impossible, at least the way you described it. A JPEG is just a picture. A PDF is a container format that can contain pictures, text, hyperlinks, et cetera.

Maybe if you told us what you were trying to do we could help you figure out a way to do it.