Hi Peter,
So this printer is a $15,000 Konice Minolta printer. It doesn't print to the edge, but it does print to 1/2 cm. Which is what this margin should be. And is on the right side of the page.
Printing as a PDF would make my margins even larger, and give me no control.
When I created the layout, to have rows and columns, I feel like I made a mistake here - which is why I posted here.
This screen shot shows the both margins. It looks as though the whole page is shifted to the left - but it doesn't print that way. The labels (circles) print exactly where they should on the paper, perfectly centered - with a 1/2 cm margin on each side.
But that fraction of each circle in the left column is cut off.
So baffling.

OK, I suspect your printer has the ability to shift the image, which is good. Your screen capture clearly shows that the lables are not aligned to the margins, and that's why the left edge is cutting off.
I don't know why you say the margins would be larger printing from PDF unless youare telling it to print the full page inside the printable area. You would want the page to print at a scale of 100%.
I sugest you make a copy of the layout, shift the labels to the right so they align with the margins and make some test pints on plain paper to start. Compare the postioning to the label die cuts and use the printer driver to shift the image if necessary, then see if the left edge is still cut off.