Maybe not, if the position of the frame is always the same; and I can assume that, because you want to use the frame on a master. And if the frame is on every spread.
The idea:
[1] Leave out the frame in your document altogether
[2] Prepare a new two spread document with facing pages and one single instance of two threaded text frames.
[3] Select the two spreads in the Pages panel and duplicate them. Select the resulting four spreads in the document and duplicate them again. And so on until you reached your maximum number of pages, 300 in your case.
[4] Export that document to pdf with the PDF/X-4 export preset
[5] Place the PDF pages in your original document on a custom layer using the MultiPageImporter script:

Download the script that was originally written by Scott Zanelli and now is curated by Mike Edel from:
https://github.com/mike-edel/ID-MultiPageImporter/releases
Regards,
Uwe Laubender
( ACP )