File allocation Units when formatting 4TB external hard drive in Windows 11 for speed in Lightroom

Windows 11 has a default NTFS allocation unit size of 4K when formatting external drives. I am intending to use  a 4TB external ssd drive. However, I understand that large files or 4K video files are better suited to larger allocation unit sizes for read/write speeds. Allocation sizes include 16K, 32K and 64K and I see that 64 K is often recommended on the internet. I have many 20MB files and now shoot between 30-50MB typically plus some 5 minute 4k video files. However, if the Lightroom catalog is saved as a zip file, can it be opened in Lightroom Classic and used if NTFS format at higher allocation sizes are used uo to 64K? As a secondary question, can previously saved Lightroom zip files, saved on a drive formatted at 4K be opened if moved to a new external SSD drive formatted at say 64K?