The Lens Profile tool is camera model aware and knows if the file was shot with a full-frame or crop sensor camera. The full-frame lens profile contains Distortion and Vignetting data for the full-frame area, including the central the crop sensor frame area, and it is applied 100% correctly. If Adobe hadn't designed it this way they would need to create at least two lens profiles for every full-frame lens model. The best example of this is the Canon EF 8-15mm F4L Fisheye lens, which Canon designed for use on both full-frame AND crop sensor EOS bodies. I have it and the single lens profile works correctly on both body types.
I started with the Canon 300D and 18-55mm kit lens, but all the lenses purchased to date are full-frame. Just keep in mind that an ultra-wide 16-35mm zoom lens becomes a modest 26-56mm equivalent focal length. However the 70-200mm zoom becomes a longer reach 112-320mm equivalent focal length. Image quality of the full-frame Canon lenses on my crop sensor bodies (300D, 600D) is quite good. They're more expensive, but if a full-frame body is on your wish-list it's a good investment! 