Hi!
I've spent about 2hours with Adobe support on remote desktop to solve this exact same issue. They totally DO NOT know that to do about it, or should I say, they don't know anything . Guy on support tried to persuade me that my network drive are what causes this problem! Asked me the same questions for at least five times. I'm totally pissed of!
Lightroom Classic 10.1 has a massive problem with GPU memory leak! Once the vido memory is more than 95% full, LcR overflows it and freezes whole system, makes it totally unusable for tens of seconds. Sometimes minutes.
The fix is quite easy, downgrade back to LrC 10.0 or disable GPU acceleration in 10.1.
This bug causes my whole system to freeze, show artifacts on screen, display green frames in video or disables video playback in macOS Big Sur 11.1 totally. Until I restart my iMac.