1) Your issue may very well be due to a LR incompatible display profile being created by your Spyder 5 software. In my reply #10 I explain how to set its software preferences to create an ICC Version 2 profile. You should also select the option for creating a "Matrix" based profile and not "LUT" profile, which some people have had issues using with LR. I'm not sure where that option is in your Spyder 5 software.
2) Some people have also seen rendering issues with the LR Preferences GPU setting enabled. What LR version are you using? Go LR Help> About and tell us the 'Release' number.
SUGGESTION (Try this first!)
Before attempting any further changes to your Spyder calibration run a quick test on the display profile. At the below link it outlines how to manually change the display profile. You have a wide gamut display, which is near 100% Adobe RGB 1998 gamut. Instead of the sRGB profile mentioned you should select and assign the Adobe RGB 1998 colror profile.
https://www.lightroomqueen.com/articles-page/how-do-i-change-my-monitor-profile-to-check-whether-its-corrupted/
After this has been completed you will need to close and then restart LR to load the newly assigned display profile. Next try editing an image with the new profile, export to sRGB profile JPEG file, and see how it appears in other color-managed applications (PS, Bridge, InfranView).