As Alek suggested:
 • Hold Option + Shift while launching Lightroom.
 • Click “Yes” when prompted to reset preferences.

This won’t delete your photos but will reset settings like interface layout and preferences. So, ensure to keep a backup of your settings.

Also, Toggle Lens Blur and Re-analyze Depth Map
 • Turn off Lens Blur
 • Go to the Masking Panel
 • Delete the existing Depth Mask (if present)
 • Recreate it using “Lens Blur > Apply” again
 • Check if it’s now correctly aligned

Additionally, sometimes the rendering glitch could be GPU-related:
 • Go to Lightroom > Preferences > Performance
 • Try toggling Use Graphics Processor to Off, then restart Lightroom
 • See if the alignment issue persists

if still not working? Please share the following so we can investigate:
 1. System Info
Go to: Help > System Info → Save it as a .txt file
 2. Screenshot of the issue
Clearly showing how the blur is misaligned from the subject
 3. Original photo (.DNG, .CR3, etc.) if you’re comfortable sharing

Let us know how it goes!

Best,

Anshul Saini