Adobe Photoshop creates lag in Windows Explorer

@TheYeager it might be an accumulation of temporary files, especially within the C:\Users\[your user name]\AppData\Local\Temp directory, which Photoshop heavily utilizes for its scratch disk operations and internal processes. While your system boasts ample RAM and a powerful GPU, a congested temp folder or a conflict with other background applications (like certain font managers or even antivirus software) can bottleneck Photoshop's ability to quickly access and interact with the file system. To address this, regularly clear your temporary files by typing %temp% into the Windows search bar and deleting the contents of the opened folder, ensure your Photoshop preferences (Edit > Preferences > Performance) are optimized with sufficient RAM allocation (typically 70-85% of your 64GB) and appropriate Cache Levels, and consider temporarily disabling any third-party font management tools or real-time antivirus scans to see if they are interfering with Photoshop's file handling. 

Speaking from experience, this was one of my issues with Illustrator as I work inIllustrator all the time. The worse case scenario, is manually deleting the Preferences folder. Don't worry, once you restart your computer, a new Preferences folder will be created. Mine went from 17 gigs to 384kb!