This worked for me too--running Windows 10 64-bit on an older laptop, and never had an issue with PS in two decades. NEFs opened fine in raw but not in PS (alarming flashing screen), and then I found I couldn't open jpegs or anything else. I thought my 2015 vintage GPU might be the cause given the system requirements, but Ged_Traynor's suggestion worked for me just fine. Thanks!