I had forgotten about this post, and after briefly scrolling over it, I can see why. It's amazing how heated a post can get when people are simply looking for answers and there are those who get offended when their answer isn't considered the ultimate solution.
RaveWolf - I appreciate the time you took to write your post, but in all reality, what you suggested is almost as manual as the other suggestions (and not easily and quickly edited) - it's hard to move a 1 px line quickly and accurately (opposed to simply dragging guide lines around).
The solution I found is to group all relative layers together, convert them into a smart object, double click the smart object (previous guide lines will accompany). Clear those guide lines and create a new set however needed). When you are finished, close the document making sure to save it, and then you are back to the original document with its original guide lines. Even if you add new guide lines to the original document, the smart object will only contain the guide lines added when editing that smart object. My problem is solved!
So, in my scenario (as if I was starting a new project), I create a new document, create an empty group naming the group according to the different page titles I may be designing (ie. home, services, contact, etc). Convert each group into a new smart object, then edit and set guide lines accordingly per smart object. This allows me to have ONE master document while being able to edit the various other documents contained in the smart object.