Photoshop Locks up on 'Save As' & 'Open'

PhotoShop CS5 Extended
Windows 10

Suddenly after years of use, Photoshop won't let me 'Save As' and locks up at the same time. I can 'Save' or "Save for Web,' but not 'Save As.' I cannot 'Save As' any file format that I edit. I cannot "Save" as new file and when closing it I am asked it I want to save it? I select 'yes' and PS locks up. I cannot use File>Open, as it locks up for that as well, but I can drag a file onto the screen and it will open. Any time iy locks up I can unlock it by hitting the 'Esc" key. I tried resetting preferences and even doing an uninstall and reinstall. Neithe of them worked. I also turned off ' Enable Open GL Drawing' under Prefernces>performance, but that didn't solve the issue either. No hardware changes have been made in 3 years and no new software for the past year, aside from updates made by the OS or software already installed.

Any other ideas?