Photoshop will not open after update

Every time I update Photoshop it refuses to open. 

And everytime I try a lot of things, and finally - ofte after 2-3 hours - I manage to get it working again. 

I use a little special setup, wich might be the issue. I am on a fast new ASUS i7 Laptop, with a RTX4050 Nvidia GPU with 32 GB RAM, SSD HDD, latest drivers and Windows 11 etc. All Adobe software runs smoothly on this machine - exceot Photoshop will not start at all. It just thinmks a little for 2-4 secs and stops. In jobmanager it shows that Photoshop is loaded, but also a Adobe Crash Processor. If I try start Photoshop fx 3 times after each other all three shows up in jobmanager. Its just hanging/crashing and nothing happens. At all!

I use two external monitors - besides the laptops own - so 3 monitors in all. 
I first managed to solve the issue by forcing Photoshop to use the Nvidia GPU. I have also solved it sometimes by run as Administrator or making it start in compatible mode etc. I havew tried disconmnecting external monitors etc. But it´s not working anymore as a single solution. When I manage to get it up working again it´s often after trying a bunch of different things - and even though I have tried noting what helped and what not, it seems to be very hard to tell what really did the trick. 
I really would like to find out what the H... is going on, as I use so much time everytime I have updated Photoshop, to get it up running again. AN when it gets up running - its stable and theres is no issues before next update. ANd I want to have keep my software (that Ive paid for) updated. 
Any clues?