Hi again.
Thanks for the updates.
So the fact you have an internal D drive with SATA is fine.
However, your installation of Premiere on that drive is probably causing you all your issues
Normally, by default, Premiere and programs like After Effects etc should reside within the operating System drive.
This is because there are hooks (or Mapping) to Audio and Video outputs and inputs etc
It looks as if you are losing that. See my setup attached Screen snips.
You have selected Adobe SRT is a Video streaming protocol. What you need is to map your Timeline audio to your System Audio card.
A fresh install on the C drive where the operating system is should cure that.
You should see something like my Audio setup that maps to the system audio for playback.
If you just install a program like Premiere on a separate drive you might also lose access to system Codecs which allow Video and Audio decoding of various formats.
This is what I would do to solve your immediate problems :
Make space on your System C drive by offloading stuff like completed videos, Pictures etc which are taking up a lot of static data space and put them on the D Drive as a Data Store.
Free up enough space so you can get all your Adobe Creative Cloud Apps on the System C drive with space left - at least 150 GB.
If you put Premiere on a separate drive you wil probably lose links to other Adobe Apps like Media Encoder and After effects etc.
I think that should solve your issues. Your Media Cache can stay on D Drive - no issues with that.
Note on reinstalling Adobe Programs on other drives
Utilities exist which allow you to move a working program to other drives.
These are programs like Aomei Partition assistant, Ease US etc. There are others. I have used the Aomei program.
They effectively allow a program to operate on another drive but the program still thinks it is working on the System C drive with all the Audio, Video mapping etc in place un-disturbed.
These utilities are also useful if you want to have a bigger System C drive for more space but don't want to reinstall the whole operating system, program set, drivers etc. Useful for Premiere users who have older versions they don't want to lose.
They allow you to 'clone' the System image and write to to a freshly formatted new drive which can be much bigger 1 TB, 2 TB etc
Always take backup of your Windows System Image and files using the Microsoft tools / System restore before doing anything like that - just as insurance.
Let us know how you get on by doing the re-install of Premiere and Creative Cloud on C system Drive when you have enough space created.