Delete media cache during ongoing project on Premiere Pro

Hello Adobe community,

I'm thinking of deleting all my media cache on pp, cause I have some trouble on playback that is new to my system. 
I've deleted the older projects cache already, but that doesn't help a lot. 
My question would be - can I do this as I'm on a running project? Or I'm I stepping into big trouble as Premiere can't adress any files any more and I have to restart import process of the footage or something like that?

thanks - best Matkus

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