effect makes clip frame multiple to four

Hi sid_2333,

Welcome to the community! Let us know the version of Pr that you are using & the effect that you have applied. 

Thanks,

Sumeet

Delete the Media Cache and Media Cache files:
https://community.adobe.com/t5/premiere-pro/faq-how-to-clear-your-media-cache-in-30-seconds-in-premiere-pro-2020/m-p/11017257/thread-id/260446?page=1

Then Sequence > Render in to out

If that doesn't work, try resetting the preferences:
https://helpx.adobe.com/in/premiere-pro/using/reset-preferences.html

If that doesn't work, try creating a new project and import the old one into it.