Lumetri Color Panel Unresponsive - Premiere Pro CC 2021

I'm extremely frustrated with Premiere. I'm finalizing a video for a client that needs to get done today, but the Lumetri Color Panel is unresponsive. I'm using the default "Color" workspace on just one monitor (I had a second but wasn't sure if that was part of the problem). Intel i9-10900k 3.7ghz, 64gb RAM, Nvidia GeForce RTX 3070. The issues are as follows (they occur individually for the most part):

- have clip selected in timeline, but Lumetri shows a different clip selected

- Lumetri panel greyed out

- Lumetri panel NOT greyed out, but unresponsive (tabs won't open, sliders won't move, etc,)

- it won't let me select another clip in the timeline. I have to save the project, and then it'll allow me to select a different clip

 EVENTUALLY, it decides to work long enough for me to fix a clip, but it's completely bogging down my workflow and output schedule.

I'm really losing patience with Premiere. The program's lack of consistency is hurting my work and my income, and that's unacceptable for a product that costs over $500/yr.