Using RH 2020.6.76 - is there a way to Disable Print and Save in the generated output?

As Peter said, a foolproof method probably doesn't exist. However if corporate policy insists, the best I think you can do is hide the obvious methods. You should be able to remove the Print button from the skin, if it exists. Then I think there are third party javascripts that claim to remove right-click menu options. They should be fairly easy to implement in RH2020 due to better standards compliance. Then if the help is called from an application, you might be able to get the developers to open the help in a custom browser window that doesn't include the menu bar (so people can't access the File > Print menu). However, I haven't had to do this for decades, so I'm not entirely certain it's possible in modern browsers.

I've seen this request so many times and the answer is the same. If your users are all within your organisation, then I believe there may be ways your IT people can do it. Otherwise the answer is no, it's built into the user's browser.

Even if it were possible, screenshots render disabling print pretty pointless.

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My site www.grainge.org includes many free Authoring and RoboHelp resources that may be of help.