AME fails to render with error code -2147483648
So I'm having severe (and seemingly out of nowhere) issues with my AME rendering. I have used AE and AME fine for the past few months on this machine with absolutely no problems until Friday/Sat/Sun.
The file fails to render out and generates the error report as shown below:

I have no idea why the source is pointing towards this random place. I haven't told it to, I have also tried creating a duplicate in that location and renaming it to fit what it expects to find, and yet, nothing.
Can anyone help? My job is contingent on me being able to render videos.
