This effect cannot be aplied becuase be intilized. Try reinstalling or contacting developer

it looks like you use a third-party plugin, and most probably it does not support your AE version so try to contact the plugin developer for help 

What happens after you reinstall the effect?

Without any info about what effect you are trying to apply, system info, version of AE and so on we can't really tell you anything. You need to be much, much, more specific.

Mylenium