What is the path from graphic design to ColdFusion projects

I've been a ColdFusion and Flex developer for way to many years now.  Pretty much turned that horse into glue if ya know what I mean.  Thing is I really like CF so I want to keep developing my business applications in that language.  Problem is I've never really developed responsive web sites nor have I made extensive use of CSS.

I'm currently playing with Muse and ReFlow and love what they do.  My only question is there a suggested workflow path for creating website designs in Muse / ReFlow and import them into a CF project?

If not why not?