your d-drive programs will still save stuff to your c drive including the folder you cited. ntl, many of those files are no longer being used. you can check them and pre-delete the one's associated with no longer installed adobe apps.
to predelete: i like to zip them and prepend the name with an underscore so they move to the alphabetical top. delete the unzipped files.
then after you're comforatble (certainly after a computer restart of programs opening with no problems), you can delete the zipped files.